Synthesis, characterization and investigation of antibacterial activity for some new functionalized luminol derivatives

ABSTRACT. The present study describes synthesis of some new luminol derivatives, which might play an important role in biological active agents. These synthesized compounds are functionalized based on (LM) with different carboxylic drugs such as mefenamic acid, ibuprofen, diclofenac sodium, and ampicillin). Synthesis processes was conducted by converting group the investigated into acid chloride reacting SOCl2. Then drug derivatives were reacted presences DMSO TEA to yield final target molecules. characterized using FTIR, NMR CHNS techniques. Besides that, their physical properties solubility also investigated. Biological activity (TH1-TH4) a pathogenic bacterium, Staphylococcus aureus (gram +ve), Escherichia (E. coli) -ve). obtained results for antibacterial showed that TH1-TH4 have higher against these types bacteria comparison pure LM compound drugs.
 
 KEY WORDS: Luminol, Mefenamic Ibuprofen, Diclofenac Ampicillin
 Bull. Chem. Soc. Ethiop. 2023, 37(1), 159-169. DOI: https://dx.doi.org/10.4314/bcse.v37i1.13